May 19, 2016
Category: General
Posted by: antiadmin

Automated assays for biological drugs.

May 19, 2016
Category: General
Posted by: antiadmin
As of May 2016, we are no longer defined as a regional core facility.


1.     Bjerner J, Bolstad N, Piehler A. Belief is only half the truth - or why screening for heterophilic antibody interference in certain assays makes double sense. Ann Clin Biochem 2012;49:381-6.

2.     Lund H, Lovsletten K, Paus E, Halvorsen TG, Reubsaet L. Immuno MS-based targeted proteomics: Highly specific, sensitive and reproducible hCG determination for clinical diagnostics and doping analysis. Anal Chem 2012.

3.     Schee K, Flatmark K, Holm R, Boye K, Paus E. Erratum to: Investigation of nonspecific cross-reacting antigen 2 as a prognostic biomarker in bone marrow plasma from colorectal cancer patients. Tumour Biol 2012;33:1263-4.

4.     Nordlund MS, Stieber P, Brustugun OT, Warren DJ, Paus E. Characteristics and clinical validity of two immunoassays for ProGRP. Tumour Biol 2012;33:1105-13.

5.     Sigstad E, Paus E, Bjoro T, Berner A, Groholt KK, Jorgensen LH, Sobrinho-Simoes M, Holm R, Warren DJ. The new molecular markers DDIT3, STT3A, ARG2 and FAM129A are not useful in diagnosing thyroid follicular tumors. Mod Pathol 2012;25:537-47.

6.     Bolstad N, Oijordsbakken M, Nustad K, Bjerner J. Human epididymis protein 4 reference limits and natural variation in a Nordic reference population. Tumour Biol 2012;33:141-8.

7.     Bolstad N, Kazaryan AM, Revheim ME, Distante S, Johnsrud K, Warren DJ, Nustad K, Edwin B. A man with abdominal pain: enough evidence for surgery? Clin Chem 2012;58:1187-90.

8.     Patel O, Clyde D, Chang M, Nordlund MS, Steel R, Kemp BE, Pritchard DM, Shulkes A, Baldwin GS. Pro-GRP-derived peptides are expressed in colorectal cancer cells and tumors and are biologically active in vivo. Endocrinology 2012;153:1082-92.

9.     Ekstrom PO, Warren DJ, Thilly WG. Separation principles of cycling temperature capillary electrophoresis. Electrophoresis 2012;33:1162-8.

10.   Asvold BO, Bjoro T, Platou C, Vatten LJ. Thyroid function and the risk of coronary heart disease: 12-year follow-up of the HUNT Study in Norway. Clin Endocrinol (Oxf) 2012.

11.   Asvold BO, Vatten LJ, Midthjell K, Bjoro T. Serum TSH within the reference range as a predictor of future hypothyroidism and hyperthyroidism: 11-year follow-up of the HUNT Study in Norway. J Clin Endocrinol Metab 2012;97:93-9.

12.   Rawal R, Teumer A, Volzke H, Wallaschofski H, Ittermann T, Asvold BO, Bjoro T, Greiser KH, Tiller D, Werdan K, Meyer Zu Schwabedissen HE, Doering A, Illig T, Gieger C, Meisinger C, Homuth G. Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function. Hum Mol Genet 2012;21:3275-82.

13.   Bolstad N, Warren DJ, Bjerner J, Kravdal G, Schwettmann L, Olsen KH, Rustad P, Nustad K. Heterophilic antibody interference in commercial immunoassays; a screening study using paired native and pre-blocked sera. Clin Chem Lab Med 2011;49:2001-6.

14.   Paus E, Hirzel K, Lidqvist M, Hoyhtya M, Warren DJ. TD-12 workshop report: characterization of monoclonal antibodies to neuron-specific enolase. Tumour Biol 2011;32:819-29.

15.   Paus E, Haugen MH, Olsen KH, Flatmark K, Maelandsmo GM, Nilsson O, Roijer E, Lundin M, Fermer C, Samsonova M, Lebedin Y, Stigbrand T. TD-11 workshop report: characterization of monoclonal antibodies to S100 proteins. Tumour Biol 2011;32:1-12.

16.   Warsame AA, Aasheim HC, Nustad K, Troen G, Tierens A, Wang V, Randen U, Dong HP, Heim S, Brech A, Delabie J. Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity. Blood 2011;118:3331-9.

17.   Warren DJ. Preparation of highly efficient electrocompetent Escherichia coli using glycerol/mannitol density step centrifugation. Anal Biochem 2011;413:206-7.

18.   Heilo A, Sigstad E, Fagerlid KH, Haskjold OI, Groholt KK, Berner A, Bjoro T, Jorgensen LH. Efficacy of ultrasound-guided percutaneous ethanol injection treatment in patients with a limited number of metastatic cervical lymph nodes from papillary thyroid carcinoma. J Clin Endocrinol Metab 2011;96:2750-5.

19.   Svare A, Nilsen TI, Bjoro T, Asvold BO, Langhammer A. Serum TSH related to measures of body mass: longitudinal data from the HUNT Study, Norway. Clin Endocrinol (Oxf) 2011;74:769-75.

20.   Bogsrud TV, Hay ID, Karantanis D, Nathan MA, Mullan BP, Wiseman GA, Kasperbauer JL, Reading CC, Bjoro T, Lowe VJ. Prognostic value of 18F-fluorodeoxyglucose-positron emission tomography in patients with differentiated thyroid carcinoma and circulating antithyroglobulin autoantibodies. Nucl Med Commun 2011;32:245-51.

21.   Asvold BO, Bjoro T, Vatten LJ. Association of thyroid function with estimated glomerular filtration rate in a population-based study: the HUNT study. Eur J Endocrinol 2011;164:101-5.

22.   Haakensen VD, Bjoro T, Luders T, Riis M, Bukholm IK, Kristensen VN, Troester MA, Homen MM, Ursin G, Borresen-Dale AL, Helland A. Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas. BMC Cancer 2011;11:332.

23.   Warren DJ, Nordlund MS, Paus E. Formulation of immunoassay calibrators in pasteurized albumin can significantly enhance their durability. J Immunol Methods 2010;353:145-7.

24.   Harvey RA, Mitchell HD, Stenman UH, Blankenstein MA, Nustad K, Stieber P, Stewart W, Savage PM, Seckl MJ, Braunstein GD. Differences in total human chorionic gonadotropin immunoassay analytical specificity and ability to measure human chorionic gonadotropin in gestational trophoblastic disease and germ cell tumors. J Reprod Med 2010;55:285-95.

25.   Holen HL, Nustad K, Aasheim HC. Activation of EphA receptors on CD4+CD45RO+ memory cells stimulates migration. J Leukoc Biol 2010;87:1059-68.

26.   Bogsrud TV, Karantanis D, Nathan MA, Mullan BP, Wiseman GA, Kasperbauer JL, Reading CC, Bjoro T, Hay ID, Lowe VJ. The prognostic value of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography in patients with suspected residual or recurrent medullary thyroid carcinoma. Mol Imaging Biol 2010;12:547-53.

27.   Nordlund MS, Warren DJ, Laerdahl JK, Paus E. Studies on multiple forms of proGRP in serum from small cell lung cancer patients. Tumour Biol 2009;30:265-75.

28.   Lund H, Torsetnes SB, Paus E, Nustad K, Reubsaet L, Halvorsen TG. Exploring the complementary selectivity of immunocapture and MS detection for the differentiation between hCG isoforms in clinically relevant samples. J Proteome Res 2009;8:5241-52.

29.   Winther B, Nordlund M, Paus E, Reubsaet L, Halvorsen TG. Immuno-capture as ultimate sample cleanup in LC-MS/MS determination of the early stage biomarker ProGRP. J Sep Sci 2009;32:2937-43.

30.   Winther B, Moi P, Nordlund MS, Lunder N, Paus E, Reubsaet JL. Absolute ProGRP quantification in a clinical relevant concentration range using LC-MS/MS and a comprehensive internal standard. J Chromatogr B Analyt Technol Biomed Life Sci 2009;877:1359-65.

31.   Warren DJ, Nustad K, Beard JB, O'Brien TJ. Expression and epitope characterization of a recombinant CA 125 repeat: fourth report from the ISOBM TD-1 workshop. Tumour Biol 2009;30:51-60.

32.   Nustad K, Nilsson O, Majnesjo K, Murakami A, Sugino N, Warren DJ, Kato H. Characterization of monoclonal antibodies directed against squamous cell carcinoma antigens: report of the second TD-10 workshop. Tumour Biol 2009;30:26-36.

33.   Bjerner J, Biernat D, Fossa SD, Bjoro T. Reference intervals for serum testosterone, SHBG, LH and FSH in males from the NORIP project. Scand J Clin Lab Invest 2009;69:873-9.

34.   Kiserud CE, Schover LR, Dahl AA, Fossa A, Bjoro T, Loge JH, Holte H, Yuan Y, Fossa SD. Do male lymphoma survivors have impaired sexual function? J Clin Oncol 2009;27:6019-26.

35.   Asvold BO, Bjoro T, Vatten LJ. Association of serum TSH with high body mass differs between smokers and never-smokers. J Clin Endocrinol Metab 2009;94:5023-7.

36.   Panicker V, Evans J, Bjoro T, Asvold BO, Dayan CM, Bjerkeset O. A paradoxical difference in relationship between anxiety, depression and thyroid function in subjects on and not on T4: findings from the HUNT study. Clin Endocrinol (Oxf) 2009;71:574-80.

37.   Svare A, Nilsen TI, Bjoro T, Forsmo S, Schei B, Langhammer A. Hyperthyroid levels of TSH correlate with low bone mineral density: the HUNT 2 study. Eur J Endocrinol 2009;161:779-86.

38.   Berg A, Dahl AA, Bruland OS, Bjoro T, Aanensen MS, Fossa SD. Definitive radiotherapy with adjuvant long-term antiandrogen treatment for locally advanced prostate cancer: health-related quality of life and hormonal changes. Prostate Cancer Prostatic Dis 2009;12:269-76.

39.    Krokeide SZ, Bolstad N, Laerdahl JK, Bjoras M, Luna L. Expression and purification of NEIL3, a human DNA glycosylase homolog. Protein Expr Purif 2009;65:160-4.

40.   Bjerner J, Hogetveit A, Wold AK, Vangsnes K, Paus E, Bjoro T, Bormer OP, Nustad K. Reference intervals for carcinoembryonic antigen (CEA), CA125, MUC1, Alfa-foeto-protein (AFP), neuron-specific enolase (NSE) and CA19.9 from the NORIP study. Scand J Clin Lab Invest 2008;68:703-13.

41.   Faye RS, Paus E, Maelandsmo GM, Berner A, Hoifodt HK, Fodstad O, Aamdal S. S100B in bone marrow aspirates in healthy individuals and malignant melanoma patients. Melanoma Res 2008;18:134-40.

42.   Nordlund MS, Warren DJ, Nustad K, Bjerner J, Paus E. Automated time-resolved immunofluorometric assay for progastrin-releasing peptide. Clin Chem 2008;54:919-22.

43.   Nordlund MS, Bjerner J, Warren DJ, Nustad K, Paus E. Progastrin-releasing peptide: stability in plasma/serum and upper reference limit. Tumour Biol 2008;29:204-10.

44.   Asvold BO, Bjoro T, Nilsen TI, Gunnell D, Vatten LJ. Thyrotropin levels and risk of fatal coronary heart disease: the HUNT study. Arch Intern Med 2008;168:855-60.

45.   Sigstad E, Heilo A, Paus E, Holgersen K, Groholt KK, Jorgensen LH, Bogsrud TV, Berner A, Bjoro T. The usefulness of detecting thyroglobulin in fine-needle aspirates from patients with neck lesions using a sensitive thyroglobulin assay. Diagn Cytopathol 2007;35:761-7.

46.   Winther B, Moi P, Paus E, Reubsaet JL. Targeted determination of the early stage SCLC specific biomarker pro-gastrin-releasing peptide (ProGRP) at clinical concentration levels in human serum using LC-MS. J Sep Sci 2007;30:2638-46.

48.   Stray-Pedersen A, Borresen-Dale AL, Paus E, Lindman CR, Burgers T, Abrahamsen TG. Alpha fetoprotein is increasing with age in ataxia-telangiectasia. Eur J Paediatr Neurol 2007;11:375-80.

49.   Nordlund MS, Fermer C, Nilsson O, Warren DJ, Paus E. Production and Characterization of Monoclonal Antibodies for Immunoassay of the Lung Cancer Marker proGRP. Tumour Biol 2007;28:100-10.

50.   Asvold BO, Bjoro T, Nilsen TI, Vatten LJ. Tobacco smoking and thyroid function: a population-based study. Arch Intern Med 2007;167:1428-32.

51.   Brydoy M, Fossa SD, Dahl O, Bjoro T. Gonadal dysfunction and fertility problems in cancer survivors. Acta Oncol 2007;46:480-9.

52.   Asvold BO, Vatten LJ, Nilsen TI, Bjoro T. The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study. Eur J Endocrinol 2007;156:181-6.

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